Selective Decontamination of the Gastrointestinal Tract: A Possible Strategy to Reduce Infection in High-Risk Populations
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چکیده
The microbial ecology in the human digestive tract is diverse and here environmental triggers, immune signals and genetic susceptibility can affect the human host’s response to infection [1]. Selective decontamination has emerged as a potential treatment for patients at high risk of infection such as those; in the critical care environments, undergoing invasive surgical operations, or with significant immunosuppression. Selective decontamination aims to vastly reduce numbers of bacteria in the gastrointestinal (GI) tract and subsequently reduce the risk of infection. There are two main approaches: selective oropharyngeal decontamination (SOD) and selective digestive decontamination (SDD) [2].
منابع مشابه
Selective decontamination of the digestive tract: an update of the evidence
Selective decontamination of the digestive tract has been proven to prevent severe infections and to reduce mortality in critically ill patients. Historical arguments against its use, like the development of bacterial resistance and the absence of influence on mortality, have not been confirmed. Recent clinical trials designed to evaluate these variables and meta-analyses showed remarkable redu...
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